Human Engineered Heart Tissue: Analysis of Contractile Force
نویسندگان
چکیده
منابع مشابه
Human Engineered Heart Tissue: Analysis of Contractile Force
Analyzing contractile force, the most important and best understood function of cardiomyocytes in vivo is not established in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). This study describes the generation of 3D, strip-format, force-generating engineered heart tissues (EHT) from hiPSC-CM and their physiological and pharmacological properties. CM were differentiated fro...
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Andrea Stoehr,* Christiane Neuber,* Christina Baldauf, Ingra Vollert, Felix W. Friedrich, Frederik Flenner, Lucie Carrier, Alexandra Eder, Sebastian Schaaf, Marc N. Hirt, Bülent Aksehirlioglu, Carl W. Tong, Alessandra Moretti, Thomas Eschenhagen, and Arne Hansen Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, M...
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Contraction and relaxation are fundamental aspects of cardiomyocyte functional biology. They reflect the response of the contractile machinery to the systolic increase and diastolic decrease of the cytoplasmic Ca(2+) concentration. The analysis of contractile function and Ca(2+) transients is therefore important to discriminate between myofilament responsiveness and changes in Ca(2+) homeostasi...
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Currently-used mechanical and biological heart valve prostheses have several disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. Xenogenous and allogenous biological prostheses are associated with immune reaction...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2016
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2016.04.011